What instruction should the nurse give for administering nitroglycerin transdermal spray?

The instruction to administer nitroglycerin transdermal spray as soon as chest pain develops is critical because nitroglycerin is designed to provide rapid relief from anginal symptoms. The mechanism of action for nitroglycerin involves the dilation of blood vessels, which helps to increase blood flow to the heart and reduces the heart's workload. Therefore, using the spray immediately when experiencing pain allows for prompt action against the anginal episode, enhancing the effectiveness of the treatment.

Delaying administration until pain persists or consulting with a care provider may lead to prolonged discomfort and potential complications, as angina can indicate underlying cardiac issues that require immediate intervention. Similarly, restricting the use of nitroglycerin to nighttime is not practical, as episodes of chest pain can occur at any time and require timely treatment. Thus, the emphasis on administering the spray at the onset of chest pain aligns with best clinical practices for managing angina pectoris.