What is a contraindication for the use of nitrates?

Cerebral hemorrhage is considered a contraindication for the use of nitrates due to the potential for increased intracranial pressure. Nitrates work by dilating blood vessels, which can lead to a reduction in blood pressure. In cases of cerebral hemorrhage, lowering blood pressure could exacerbate the bleeding or worsen the patient's condition by increasing the risk of further complications, such as increased cerebral edema or re-bleeding.

While hypotension, liver dysfunction, and hypovolemia are factors that require caution or dosage adjustments when using nitrates, they do not serve as absolute contraindications. Patients with hypotension may need to avoid nitrates because these medications can lower blood pressure further, but it isn't an outright prohibition as individual circumstances may allow for careful administration under medical supervision. Liver dysfunction can affect drug metabolism, requiring careful monitoring but is not a direct contraindication. Hypovolemia can also lead to hypotension but does not outright prevent the use of nitrates, though they should be used cautiously in these situations.