What is the significance of nitrate tolerance?

Nitrate tolerance refers to the phenomenon where the effectiveness of nitrates, which are commonly used as antianginal agents, diminishes with continuous exposure. This tolerance can develop because the body adjusts to the consistent presence of the drug, leading to a reduced response over time. Consequently, patients may find that the same dosage of nitrates becomes less effective at alleviating angina symptoms after prolonged use.

This understanding is crucial for managing treatment effectively. Clinicians recognize the need to periodically withhold nitrates or adjust dosages to avoid tolerance and maintain their therapeutic efficacy. By incorporating drug-free intervals or using alternative treatments, healthcare providers can help mitigate the development of tolerance and ensure that nitrates remain effective for their patients.