Which agents are known to increase the risk of bleeding when interacting with warfarin?

Salicylates, such as aspirin, are known to increase the risk of bleeding when interacting with warfarin. This occurs because salicylates inhibit platelet aggregation, which is the process by which platelets clump together to form blood clots. When combined with warfarin, which is an anticoagulant that prevents clotting by inhibiting vitamin K-dependent coagulation factors, the risk of bleeding complications can significantly rise.

It is important to monitor patients on both warfarin and salicylates closely, as the synergistic effects of these medications can lead to an increased risk of serious bleeding events. This interaction is particularly crucial in clinical settings, where management of anticoagulation therapy is vital for maintaining patient safety.

Other agents mentioned, like barbiturates, ceftriaxone, and furosemide, have their own interactions with warfarin but do not specifically increase the bleeding risk in the same manner as salicylates. Their interactions may involve changes in warfarin metabolism or displacement from protein-binding sites rather than a direct increase in bleeding risk.