Which of the following is NOT a role of ACE inhibitors?

ACE inhibitors, or angiotensin-converting enzyme inhibitors, have several well-established roles in managing cardiovascular health, particularly for conditions like heart failure and hypertension.

Improving heart function is a primary benefit of ACE inhibitors. They help prevent the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to vasodilation, reduced cardiac workload, and improved efficiency in heart function, particularly in patients with heart failure.

Lowering blood pressure is another critical function of ACE inhibitors. By blocking the formation of angiotensin II, they facilitate easier blood flow through the blood vessels, thereby reducing blood pressure. This property is especially beneficial for patients with hypertension.

Reducing afterload is also a significant effect resulting from the use of ACE inhibitors. Afterload is the resistance the heart must overcome to eject blood during systole. By promoting vasodilation and reducing systemic vascular resistance, ACE inhibitors effectively decrease afterload, making it easier for the heart to pump blood.

Increasing cholesterol levels, on the other hand, is not a role of ACE inhibitors. In fact, these medications do not impact cholesterol levels directly and are primarily focused on influencing the renin-angiotensin system to achieve their cardiovascular effects.