Which of the following should be monitored when a patient is on long-term nitroglycerin therapy?

When a patient is on long-term nitroglycerin therapy, it is crucial to monitor for signs of tolerance. Tolerance to nitroglycerin can develop when it is used continuously, leading to reduced effectiveness over time. This is particularly relevant because nitroglycerin acts as a vasodilator, and if a patient becomes tolerant, they may not experience the expected relief from angina. Monitoring for signs of tolerance includes assessing the frequency and severity of angina attacks, as well as the need for increased dosages of the medication to achieve the desired effect.

Other considerations, such as blood glucose levels, respiratory rate, and creatinine levels, may be important in the context of a patient’s overall health or in relation to other medications or conditions, but they are not directly related to the effects of long-term nitroglycerin therapy. Therefore, focusing on tolerance provides essential guidance for effective and safe management of a patient’s angina.